Global Analysis of the Staphylococcus aureus Response to Mupirocin

In the present study, we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRS), leading to the accumulation of uncharged isoleucyl-tRNA and eventually the synthesis of (p)ppGpp. The...

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Autores principales: Reiß, Swantje, Pané-Farré, Jan, Fuchs, Stephan, François, Patrice, Liebeke, Manuel, Schrenzel, Jacques, Lindequist, Ulrike, Lalk, Michael, Wolz, Christiane, Hecker, Michael, Engelmann, Susanne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264241/
https://ncbi.nlm.nih.gov/pubmed/22106209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05363-11
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