Global Analysis of the Staphylococcus aureus Response to Mupirocin

In the present study, we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRS), leading to the accumulation of uncharged isoleucyl-tRNA and eventually the synthesis of (p)ppGpp. The...

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Detalhes bibliográficos
Main Authors: Reiß, Swantje, Pané-Farré, Jan, Fuchs, Stephan, François, Patrice, Liebeke, Manuel, Schrenzel, Jacques, Lindequist, Ulrike, Lalk, Michael, Wolz, Christiane, Hecker, Michael, Engelmann, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264241/
https://ncbi.nlm.nih.gov/pubmed/22106209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05363-11
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