Synergistic Inhibition of Butyrylcholinesterase by Galantamine and Citalopram

BACKGROUND: Many persons with Alzheimer’s disease (AD) treated with galantamine appear to receive additional cognitive benefit from citalopram. Both drugs inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). These enzymes co-regulate acetylcholine catabolism. In AD brain, AChE is d...

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Main Authors: Walsh, Ryan, Rockwood, Kenneth, Martin, Earl, Darvesh, Sultan
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263522/
https://ncbi.nlm.nih.gov/pubmed/21872646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2011.08.010
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