RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replication. Misincorporation is limited by the selectivity of DNA replicases. We show that accumulation of ribonu...

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Main Authors: Lazzaro, Federico, Novarina, Daniele, Amara, Flavio, Watt, Danielle L., Stone, Jana E., Costanzo, Vincenzo, Burgers, Peter M., Kunkel, Thomas A., Plevani, Paolo, Muzi-Falconi, Marco
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262129/
https://ncbi.nlm.nih.gov/pubmed/22244334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.019
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