RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replication. Misincorporation is limited by the selectivity of DNA replicases. We show that accumulation of ribonu...

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Autors principals: Lazzaro, Federico, Novarina, Daniele, Amara, Flavio, Watt, Danielle L., Stone, Jana E., Costanzo, Vincenzo, Burgers, Peter M., Kunkel, Thomas A., Plevani, Paolo, Muzi-Falconi, Marco
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262129/
https://ncbi.nlm.nih.gov/pubmed/22244334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.019
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