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Three-Component Coupling Sequence for the Regiospecific Synthesis of Substituted Pyridines

A de novo synthesis of substituted pyridines is described that proceeds through nucleophilic addition of a dithiane anion to an α,β-unsaturated carbonyl followed by metallacycle-mediated union of the resulting allylic alcohol with preformed TMS-imines (generated in situ by the low temperature reacti...

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Detalhes bibliográficos
Main Authors: Chen, Ming Z., Micalizio, Glenn C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262091/
https://ncbi.nlm.nih.gov/pubmed/22103772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2105703
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