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Synthesis of Angularly Substituted trans-Fused Decalins by a Metallacycle-Mediated Annulative Cross-Coupling Cascade

A convergent coupling reaction is described that enables the stereoselective construction of angularly substituted trans-fused decalins from acyclic precursors. The process builds on our alkoxide-directed titanium-mediated alkyne–alkyne coupling and employs a 1,7-enyne coupling partner. Overall, the...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Mizoguchi, Haruki, Micalizio, Glenn C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056368/
https://ncbi.nlm.nih.gov/pubmed/27634059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201606962
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