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Determinants of the cytotoxicity of PrrC anticodon nuclease and its amelioration by tRNA repair

Breakage of tRNA(Lys(UUU)) by the Escherichia coli anticodon nuclease PrrC (EcoPrrC) underlies a host antiviral response to phage T4 infection that is ultimately thwarted by a virus-encoded RNA repair system. PrrC homologs are prevalent in other bacteria, but their activities and substrates are not...

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Autors principals: Meineke, Birthe, Shuman, Stewart
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261736/
https://ncbi.nlm.nih.gov/pubmed/22101242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.030171.111
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