Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery

Chemically stabilized small interfering RNA (siRNA) can be delivered systemically by intravenous injection of lipid nanoparticles (LNPs) in rodents and primates. The biodistribution and kinetics of LNP–siRNA delivery in mice at organ and cellular resolution have been studied using immunofluorescence...

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Detalhes bibliográficos
Main Authors: Shi, Bin, Keough, Ed, Matter, Andrea, Leander, Karen, Young, Stephanie, Carlini, Ed, Sachs, Alan B., Tao, Weikang, Abrams, Marc, Howell, Bonnie, Sepp-Lorenzino, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261601/
https://ncbi.nlm.nih.gov/pubmed/21804077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155411410885
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