Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

Mouse models with liver-specific expression of firefly luciferase were developed that enable a noninvasive and longitudinal assessment of small-interfering RNA (siRNA)–mediated gene silencing in hepatocytes of live animals via bioluminescence imaging. Using these models, a set of lipid nanoparticles...

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Autors principals: Tao, Weikang, Davide, Joseph P, Cai, Mingmei, Zhang, Guo-Jun, South, Victoria J, Matter, Andrea, Ng, Bruce, Zhang, Ye, Sepp-Lorenzino, Laura
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956923/
https://ncbi.nlm.nih.gov/pubmed/20628357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.147
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