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On the statistical properties of family-based association tests in datasets containing both pedigrees and unrelated case–control samples

A common approach to genetic mapping of loci for complex diseases is to perform a genome-wide association study (GWAS) by analyzing a vast number of SNP markers in cohorts of unrelated cases and controls. A direct motivation for the case–control design is that unrelated, affected individuals can be...

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Detalhes bibliográficos
Main Authors: Hiekkalinna, Tero, Göring, Harald HH, Lambert, Brian, Weiss, Kenneth M, Norrgrann, Petri, Schäffer, Alejandro A, Terwilliger, Joseph D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260916/
https://ncbi.nlm.nih.gov/pubmed/21934707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.173
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