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On the validity of the likelihood ratio test and consistency of resulting parameter estimates in joint linkage and linkage disequilibrium analysis under improperly specified parametric models
It has been shown that parametric analysis of linkage disequilibrium conditional on linkage using an overly deterministic model can be optimal for family-based association analysis. However if one applies this strategy carelessly there is a risk of false inference. We analyze properties of such like...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442930/ https://ncbi.nlm.nih.gov/pubmed/22082140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-1809.2011.00683.x |
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