Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1

Precise regulation of Rag (recombination-activating gene) expression is crucial to prevent genomic instability caused by the generation of Rag-mediated DNA breaks. Although mechanisms of Rag activation have been well characterized, the mechanism by which Rag expression is down-regulated in early B c...

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Hlavní autoři: Schulz, Danae, Vassen, Lothar, Chow, Kwan T., McWhirter, Sarah M., Amin, Rupesh H., Möröy, Tarik, Schlissel, Mark S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260878/
https://ncbi.nlm.nih.gov/pubmed/22201127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110645
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