Pigment Epithelium-Derived Factor Regulates Early Pancreatic Fibrotic Responses and Suppresses the Profibrotic Cytokine Thrombospondin-1

Pigment epithelium-derived factor (PEDF) is important for maintaining the normal extracellular matrix. We hypothesized that the initiation of pancreatic fibrosis is dependent on the loss of PEDF. Pancreatic PEDF expression was assessed in wild-type mice fed either a control or ethanol diet using an...

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Détails bibliographiques
Auteurs principaux: Schmitz, John C., Protiva, Petr, Gattu, Arijeet K., Utsumi, Teruo, Iwakiri, Yasuko, Neto, Antonio G., Quinn, Margo, Cornwell, Mona L., Fitchev, Philip, Lugea, Aurelia, Crawford, Susan E., Chung, Chuhan
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2011
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260804/
https://ncbi.nlm.nih.gov/pubmed/21964188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.009
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