Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content

Pigment epithelium-derived factor (PEDF), the protein product of the SERPINF1 gene, has been linked to distinct diseases involving adipose or bone tissue, the metabolic syndrome, and osteogenesis imperfecta (OI) type VI. Since mesenchymal stem cell (MSC) differentiation into adipocytes vs. osteoblas...

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Autors principals: Gattu, Arijeet K., Swenson, E. Scott, Iwakiri, Yasuko, Samuel, Varman T., Troiano, Nancy, Berry, Ryan, Church, Christopher D., Rodeheffer, Matthew S., Carpenter, Thomas O., Chung, Chuhan
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2013
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804749/
https://ncbi.nlm.nih.gov/pubmed/23887690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-232900
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