Pigment Epithelium-Derived Factor (PEDF) Suppresses IL-1β-Mediated c-Jun N-Terminal Kinase (JNK) Activation to Improve Hepatocyte Insulin Signaling

Pigment epithelium-derived factor (PEDF) is an antiinflammatory protein that circulates at high levels in the metabolic syndrome. Metabolic studies of PEDF knockout (KO) mice were conducted to investigate the relationship between PEDF, inflammatory markers, and metabolic homeostasis. Male PEDF KO mi...

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Vydáno v:Endocrinology
Hlavní autoři: Gattu, Arijeet K., Birkenfeld, Andreas L., Iwakiri, Yasuko, Jay, Steven, Saltzman, Mark, Doll, Jennifer, Protiva, Petr, Samuel, Varman T., Crawford, Susan E., Chung, Chuhan
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2014
Témata:
Growth Factors-Cytokines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393334/
https://ncbi.nlm.nih.gov/pubmed/24456163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1785
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