Pigment Epithelium-Derived Factor (PEDF) Suppresses IL-1β-Mediated c-Jun N-Terminal Kinase (JNK) Activation to Improve Hepatocyte Insulin Signaling

Pigment epithelium-derived factor (PEDF) is an antiinflammatory protein that circulates at high levels in the metabolic syndrome. Metabolic studies of PEDF knockout (KO) mice were conducted to investigate the relationship between PEDF, inflammatory markers, and metabolic homeostasis. Male PEDF KO mi...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Gattu, Arijeet K., Birkenfeld, Andreas L., Iwakiri, Yasuko, Jay, Steven, Saltzman, Mark, Doll, Jennifer, Protiva, Petr, Samuel, Varman T., Crawford, Susan E., Chung, Chuhan
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Growth Factors-Cytokines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393334/
https://ncbi.nlm.nih.gov/pubmed/24456163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1785
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