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Absence of Nogo-B (Reticulon 4B) Facilitates Hepatic Stellate Cell Apoptosis and Diminishes Hepatic Fibrosis in Mice

Nogo-B (reticulon 4B) accentuates hepatic fibrosis and cirrhosis, but the mechanism remains unclear. The aim of this study was to identify the role of Nogo-B in hepatic stellate cell (HSC) apoptosis in cirrhotic livers. Cirrhosis was generated by carbon tetrachloride inhalation in wild-type (WT) and...

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Autors principals: Tashiro, Keitaro, Satoh, Ayano, Utsumi, Teruo, Chung, Chuhan, Iwakiri, Yasuko
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586693/
https://ncbi.nlm.nih.gov/pubmed/23313137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.11.032
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