An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of Kupffer cell polarization

BACKGROUND: Nogo-B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function. Since ER stress is known to induce M2 macrophage polarization, we examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcohol...

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Bibliografiske detaljer
Udgivet i:Hepatology
Main Authors: Park, Jin-Kyu, Shao, Mingjie, Kim, Moon Young, Baik, Soon Koo, Cho, Mee Yon, Utsumi, Teruo, Satoh, Ayano, Ouyang, Xinsho, Chung, Chuhan, Iwakiri, Yasuko
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397326/
https://ncbi.nlm.nih.gov/pubmed/28090670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29051
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