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Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4

The human thromboxane A2 receptor (TP), belongs to the prostanoid subfamily of Class A GPCRs and mediates vasoconstriction and promotes thrombosis on binding to thromboxane (TXA2). In Class A GPCRs, transmembrane (TM) helix 4 appears to be a hot spot for non-synonymous single nucleotide polymorphic...

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Autors principals: Chakraborty, Raja, Pydi, Sai Prasad, Gleim, Scott, Dakshinamurti, Shyamala, Hwa, John, Chelikani, Prashen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260207/
https://ncbi.nlm.nih.gov/pubmed/22272267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029996
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