Kinesin Light Chain 1 Suppression Impairs Human Embryonic Stem Cell Neural Differentiation and Amyloid Precursor Protein Metabolism

The etiology of sporadic Alzheimer disease (AD) is largely unknown, although evidence implicates the pathological hallmark molecules amyloid beta (Aβ) and phosphorylated Tau. Work in animal models suggests that altered axonal transport caused by Kinesin-1 dysfunction perturbs levels of both Aβ and p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Killian, Rhiannon L., Flippin, Jessica D., Herrera, Cheryl M., Almenar-Queralt, Angels, Goldstein, Lawrence S. B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260181/
https://ncbi.nlm.nih.gov/pubmed/22272245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029755
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