Kinesin Light Chain 1 Suppression Impairs Human Embryonic Stem Cell Neural Differentiation and Amyloid Precursor Protein Metabolism

The etiology of sporadic Alzheimer disease (AD) is largely unknown, although evidence implicates the pathological hallmark molecules amyloid beta (Aβ) and phosphorylated Tau. Work in animal models suggests that altered axonal transport caused by Kinesin-1 dysfunction perturbs levels of both Aβ and p...

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Bibliografiska uppgifter
Huvudupphovsmän: Killian, Rhiannon L., Flippin, Jessica D., Herrera, Cheryl M., Almenar-Queralt, Angels, Goldstein, Lawrence S. B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260181/
https://ncbi.nlm.nih.gov/pubmed/22272245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029755
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