Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

The O-GlcNAc post-translational modification is considered to act as a sensor of nutrient flux through the hexosamine biosynthetic pathway. A cornerstone of this hypothesis is that global elevation of protein O-GlcNAc levels, typically induced with the non-selective O-GlcNAcase inhibitor PUGNAc (O-(...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Macauley, Matthew S., Bubb, Abigail K., Martinez-Fleites, Carlos, Davies, Gideon J., Vocadlo, David J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Glycobiology and Extracellular Matrices
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259902/
https://ncbi.nlm.nih.gov/pubmed/18842583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804525200
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