Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Ca(v)1.2 Phosphorylation Site S1928A Mutant Mice

Phosphorylation of serine 1928 (Ser(1928)) of the cardiac Ca(v)1.2 subunit of L-type Ca(2+) channels has been proposed as the mechanism for regulation of L-type Ca(2+) channels by protein kinase A (PKA). To test this directly in vivo, we generated a knock-in mouse with targeted mutation of Ser(1928)...

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Main Authors: Lemke, Toni, Welling, Andrea, Christel, Carl Johannes, Blaich, Anne, Bernhard, Dominik, Lenhardt, Peter, Hofmann, Franz, Moosmang, Sven
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259877/
https://ncbi.nlm.nih.gov/pubmed/18829456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804981200
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