Targeting Artificial Transcription Factors to the Utrophin A Promoter: EFFECTS ON DYSTROPHIC PATHOLOGY AND MUSCLE FUNCTION

Duchenne muscular dystrophy is caused by a genetic defect in the dystrophin gene. The absence of dystrophin results in muscle fiber necrosis and regeneration, leading to progressive muscle fiber loss. Utrophin is a close analogue of dystrophin. A substantial, ectopic expression of utrophin in the ex...

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Detalhes bibliográficos
Main Authors: Lu, Yifan, Tian, Chai, Danialou, Gawiyou, Gilbert, Rénald, Petrof, Basil J., Karpati, George, Nalbantoglu, Josephine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259868/
https://ncbi.nlm.nih.gov/pubmed/18945675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804518200
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