Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors

In this study, eight different HIV-1 integrase proteins containing mutations observed in strand transfer inhibitor-resistant viruses were expressed, purified, and used for detailed enzymatic analyses. All the variants examined were impaired for strand transfer activity compared with the wild type en...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dicker, Ira B., Terry, Brian, Lin, Zeyu, Li, Zhufang, Bollini, Sagarika, Samanta, Himadri K., Gali, Volodymyr, Walker, Michael A., Krystal, Mark R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Enzyme Catalysis and Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259799/
https://ncbi.nlm.nih.gov/pubmed/18577511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804213200
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