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3′-Processing and strand transfer catalysed by retroviral integrase in crystallo
Retroviral integrase (IN) is responsible for two consecutive reactions, which lead to insertion of a viral DNA copy into a host cell chromosome. Initially, the enzyme removes di- or trinucleotides from viral DNA ends to expose 3′-hydroxyls attached to the invariant CA dinucleotides (3′-processing re...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395085/ https://ncbi.nlm.nih.gov/pubmed/22580823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.118 |
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