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Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors
In this study, eight different HIV-1 integrase proteins containing mutations observed in strand transfer inhibitor-resistant viruses were expressed, purified, and used for detailed enzymatic analyses. All the variants examined were impaired for strand transfer activity compared with the wild type en...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259799/ https://ncbi.nlm.nih.gov/pubmed/18577511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804213200 |
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