Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via the ERK1/2 Signaling Pathway

Grb2-associated binder 1 (Gab1) coordinates various receptor tyrosine kinase signaling pathways. Although skeletal muscle differentiation is regulated by some growth factors, it remains elusive whether Gab1 coordinates myogenic signals. Here, we examined the molecular mechanism of insulin-like growt...

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Detalhes bibliográficos
Main Authors: Koyama, Tatsuya, Nakaoka, Yoshikazu, Fujio, Yasushi, Hirota, Hisao, Nishida, Keigo, Sugiyama, Shoko, Okamoto, Kitaro, Yamauchi-Takihara, Keiko, Yoshimura, Michihiro, Mochizuki, Seibu, Hori, Masatsugu, Hirano, Toshio, Mochizuki, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259763/
https://ncbi.nlm.nih.gov/pubmed/18577518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803907200
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