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A ROLE FOR GAB1/SHP2 IN THROMBIN ACTIVATION OF PAK1: GENE TRANSFER OF KINASE-DEAD PAK1 INHIBITS INJURY-INDUCED RESTENOSIS

To understand the contribution of EGFR transactivation in GPCR agonist-induced signaling events, we have studied the capacity of thrombin in the activation of Gab1-SHP2 in vascular smooth muscle cells (VSMCs). Thrombin activated both Gab1 and SHP2 in a time- and EGFR-dependent manner. Similarly, thr...

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Detalhes bibliográficos
Main Authors: Wang, Dong, Paria, Biman C., Zhang, Qiuhua, Karpurapu, Manjula, Li, Quanyi, Gerthoffer, William T., Nakaoka, Yoshikazu, Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814372/
https://ncbi.nlm.nih.gov/pubmed/19359598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.196691
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