Disrupted RabGAP Function of the p85 Subunit of Phosphatidylinositol 3-Kinase Results in Cell Transformation

Rab proteins regulate vesicle fusion events during the endocytosis, recycling, and degradation of activated receptor tyrosine kinases. The p85α subunit of phosphatidylinositol 3-kinase has GTPase-activating protein activity toward Rab5 and Rab4, an activity severely reduced by a single point mutatio...

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Main Authors: Chamberlain, M. Dean, Chan, Tim, Oberg, Jennifer C., Hawrysh, Andrea D., James, Kristy M., Saxena, Anurag, Xiang, Jim, Anderson, Deborah H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259639/
https://ncbi.nlm.nih.gov/pubmed/18387942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800941200
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