A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are membrane associated, but whether membrane trafficking controls Aβ levels is unclear. Here, we perfo...

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Main Authors: Udayar, Vinod, Buggia-Prévot, Virginie, Guerreiro, Rita L., Siegel, Gabriele, Rambabu, Naresh, Soohoo, Amanda L., Ponnusamy, Moorthi, Siegenthaler, Barbara, Bali, Jitin, Guerreiro, Rita, Brás, José, Sassi, Celeste, Gibbs, J. Raphael, Hernandez, Dena, Lupton, Michelle K., Brown, Kristelle, Morgan, Kevin, Powell, John, Singleton, Andrew, Hardy, John, Simons, Mikael, Ries, Jonas, Puthenveedu, Manojkumar A., Thinakaran, Gopal, Rajendran, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004174/
https://ncbi.nlm.nih.gov/pubmed/24373285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.005
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