CD40 Blockade Combines with CTLA4Ig and Sirolimus To Produce Mixed Chimerism in an MHC-defined Rhesus Macaque Transplant Model

In murine models, T-cell costimulation blockade of the CD28:B7 and CD154:CD40 pathways synergistically promotes immune tolerance after transplantation. While CD28 blockade has been successfully translated to the clinic, translation of blockade of the CD154:CD40 pathway has been less successful, in l...

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Hauptverfasser: Page, Andrew, Srinivasan, Swetha, Singh, Karnail, Russell, Maria, Hamby, Kelly, Deane, Taylor, Sen, Sharon, Stempora, Linda, Leopardi, Frank, Price, Andrew A., Strobert, Elizabeth, Reimann, Keith A., Kirk, Allan D., Larsen, Christian P., Kean, Leslie S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259212/
https://ncbi.nlm.nih.gov/pubmed/21929643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03737.x
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