An MHC-defined primate model reveals significant rejection of bone marrow after mixed-chimerism induction despite full MHC matching

In murine models, mixed hematopoietic chimerism-induction leads to robust immune tolerance. However, translation to primates and to patients has been difficult. In this study, we used a novel MHC-defined rhesus macaque model to examine the impact of MHC matching on the stability of costimulation blo...

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Detalhes bibliográficos
Main Authors: Larsen, Christian P., Page, Andrew, Linzie, Kelly Hamby, Russell, Maria, Deane, Taylor, Stempora, Linda, Strobert, Elizabeth, Penedo, Maria Cecilia T., Ward, Thea, Wiseman, Roger, O'Connor, David, Miller, Weston, Sen, Sharon, Singh, Karnail, Kean, Leslie S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980834/
https://ncbi.nlm.nih.gov/pubmed/20849552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03272.x
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