An MHC-defined primate model reveals significant rejection of bone marrow after mixed-chimerism induction despite full MHC matching

In murine models, mixed hematopoietic chimerism-induction leads to robust immune tolerance. However, translation to primates and to patients has been difficult. In this study, we used a novel MHC-defined rhesus macaque model to examine the impact of MHC matching on the stability of costimulation blo...

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Bibliografische gegevens
Hoofdauteurs: Larsen, Christian P., Page, Andrew, Linzie, Kelly Hamby, Russell, Maria, Deane, Taylor, Stempora, Linda, Strobert, Elizabeth, Penedo, Maria Cecilia T., Ward, Thea, Wiseman, Roger, O'Connor, David, Miller, Weston, Sen, Sharon, Singh, Karnail, Kean, Leslie S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980834/
https://ncbi.nlm.nih.gov/pubmed/20849552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03272.x
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