GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28(−) CD8(+) T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

We have developed a major histocompatibility complex–defined primate model of graft-versus-host disease (GVHD) and have determined the effect that CD28/CD40-directed costimulation blockade and sirolimus have on this disease. Severe GVHD developed after haploidentical transplantation without prophyla...

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Hlavní autoři: Miller, Weston P., Srinivasan, Swetha, Panoskaltsis-Mortari, Angela, Singh, Karnail, Sen, Sharon, Hamby, Kelly, Deane, Taylor, Stempora, Linda, Beus, Jonathan, Turner, Alexa, Wheeler, Caleb, Anderson, Daniel C., Sharma, Prachi, Garcia, Anapatricia, Strobert, Elizabeth, Elder, Eric, Crocker, Ian, Crenshaw, Timothy, Penedo, M. Cecilia T., Ward, Thea, Song, Mingqing, Horan, John, Larsen, Christian P., Blazar, Bruce R., Kean, Leslie S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012549/
https://ncbi.nlm.nih.gov/pubmed/20833977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-289272
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