GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28(−) CD8(+) T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

We have developed a major histocompatibility complex–defined primate model of graft-versus-host disease (GVHD) and have determined the effect that CD28/CD40-directed costimulation blockade and sirolimus have on this disease. Severe GVHD developed after haploidentical transplantation without prophyla...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Miller, Weston P., Srinivasan, Swetha, Panoskaltsis-Mortari, Angela, Singh, Karnail, Sen, Sharon, Hamby, Kelly, Deane, Taylor, Stempora, Linda, Beus, Jonathan, Turner, Alexa, Wheeler, Caleb, Anderson, Daniel C., Sharma, Prachi, Garcia, Anapatricia, Strobert, Elizabeth, Elder, Eric, Crocker, Ian, Crenshaw, Timothy, Penedo, M. Cecilia T., Ward, Thea, Song, Mingqing, Horan, John, Larsen, Christian P., Blazar, Bruce R., Kean, Leslie S.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: American Society of Hematology 2010
বিষয়গুলি:
Transplantation
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012549/
https://ncbi.nlm.nih.gov/pubmed/20833977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-289272
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