The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism But With A Significant Risk of CMV Reactivation and Disease in Rhesus Macaques

While stable mixed-hematopoietic chimerism induces robust immune tolerance to solid organ allografts in mice, the translation of this strategy to large animal models and to patients has been challenging. We have previously shown that in MHC-matched NHP, a busulfan plus combined belatacept and anti-C...

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Publicat a:Am J Transplant
Autors principals: Zheng, Hengqi (Betty), Watkins, Benjamin, Tkachev, Victor, Yu, Shan, Tran, Dollnovan, Furlan, Scott, Zeleski, Katie, Singh, Karnail, Hamby, Kelly, Hotchkiss, Charlotte, Lane, Jennifer, Gumber, Sanjeev, Adams, Andrew, Cendales, Linda, Kirk, Allan D., Kaur, Amitinder, Blazar, Bruce R., Larsen, Christian P., Kean, Leslie S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338742/
https://ncbi.nlm.nih.gov/pubmed/27500470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14006
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