ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites

PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dnmt1 [DNA (cytosine-5)-methyltransferase 1] activity. Our previous findings indicated that Ctcf (CCCTC-binding factor) may be an important player in key events whereby PARylatio...

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Main Authors: Zampieri, Michele, Guastafierro, Tiziana, Calabrese, Roberta, Ciccarone, Fabio, Bacalini, Maria G., Reale, Anna, Perilli, Mariagrazia, Passananti, Claudio, Caiafa, Paola
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258657/
https://ncbi.nlm.nih.gov/pubmed/21985173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111417
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