Parp1 Localizes within the Dnmt1 Promoter and Protects Its Unmethylated State by Its Enzymatic Activity

BACKGROUND: Aberrant hypermethylation of CpG islands in housekeeping gene promoters and widespread genome hypomethylation are typical events occurring in cancer cells. The molecular mechanisms behind these cancer-related changes in DNA methylation patterns are not well understood. Two questions are...

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Detalhes bibliográficos
Main Authors: Zampieri, Michele, Passananti, Claudio, Calabrese, Roberta, Perilli, Mariagrazia, Corbi, Nicoletta, De Cave, Fabiana, Guastafierro, Tiziana, Bacalini, Maria Giulia, Reale, Anna, Amicosante, Gianfranco, Calabrese, Lilia, Zlatanova, Jordanka, Caiafa, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650799/
https://ncbi.nlm.nih.gov/pubmed/19262751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004717
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