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Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination

It is of pivotal importance for genome stability that repair DNA polymerases (Pols), such as Pols λ and β, which all exhibit considerably reduced fidelity when replicating undamaged DNA, are tightly regulated, because their misregulation could lead to mutagenesis. Recently, we found that the correct...

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Main Authors: Markkanen, Enni, van Loon, Barbara, Ferrari, Elena, Parsons, Jason L., Dianov, Grigory L., Hübscher, Ulrich
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258598/
https://ncbi.nlm.nih.gov/pubmed/22203964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110449109
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