Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

Removal of the fucose residue from the N-glycans of the Fc portion of immunoglobulin G (IgG) results in a dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC) through improved affinity for Fcγ receptor IIIa (FcγRIIIa). Here, we present the 2.2-Å structure of the complex formed bet...

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Hlavní autoři: Mizushima, Tsunehiro, Yagi, Hirokazu, Takemoto, Emi, Shibata-Koyama, Mami, Isoda, Yuya, Iida, Shigeru, Masuda, Kazuhiro, Satoh, Mitsuo, Kato, Koichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2011
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258418/
https://ncbi.nlm.nih.gov/pubmed/22023369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2443.2011.01552.x
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