ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

DNA double-strand breaks (DSBs) threaten genome stability in all kingdoms of life and are linked to cancerogenic chromosome aberrations in humans. The Mre11:Rad50 (MR) complex is an evolutionarily conserved complex of two Rad50 ATPases and a dimer of the Mre11 nuclease that senses and processes DSBs...

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Bibliographic Details
Main Authors: Möckel, Carolin, Lammens, Katja, Schele, Alexandra, Hopfner, Karl-Peter
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258140/
https://ncbi.nlm.nih.gov/pubmed/21937514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr749
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