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Polymerization and nucleic acid-binding properties of human L1 ORF1 protein

The L1 (LINE 1) retrotransposable element encodes two proteins, ORF1p and ORF2p. ORF2p is the L1 replicase, but the role of ORF1p is unknown. Mouse ORF1p, a coiled-coil-mediated trimer of ∼42-kDa monomers, binds nucleic acids and has nucleic acid chaperone activity. We purified human L1 ORF1p expres...

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Bibliografski detalji
Glavni autori: Callahan, Kathryn E., Hickman, Alison B., Jones, Charles E., Ghirlando, Rodolfo, Furano, Anthony V.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258132/
https://ncbi.nlm.nih.gov/pubmed/21937507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr728
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