Bi-modal Dose-dependent Cardiac Response to Tetrahydrobiopterin in Pressure-overload Induced Hypertrophy and Heart Failure

The exogenous administration of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), has been shown to reduce left ventricular hypertrophy, fibrosis, and cardiac dysfunction in mice with pre-established heart disease induced by pressure-overload. In this setting, BH4 re-c...

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Bibliographic Details
Main Authors: Moens, An L., Ketner, Elizabeth A., Takimoto, Eiki, Schmidt, Tim S., O'Neill, Charles A., Wolin, Michael S., Alp, Nicholas J, Channon, Keith M., Kass, David A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257520/
https://ncbi.nlm.nih.gov/pubmed/21645517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.05.017
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