Endogenous Muscle Atrophy F-box Mediates Pressure Overload-Induced Cardiac Hypertrophy through Regulation of NF-κB

RATIONALE: Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure remains unclear. OBJECTIVE: We investigated the role of MAFbx in regulating cardi...

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Hlavní autoři: Usui, Soichiro, Maejima, Yasuhiro, Pain, Jayashree, Hong, Chull, Cho, Jaeyeaon, Park, Ji Yeon, Zablocki, Daniela, Tian, Bin, Glass, David J., Sadoshima, Junichi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257317/
https://ncbi.nlm.nih.gov/pubmed/21617130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.238717
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