Lipid Exchange Mechanism of the Cholesteryl Ester Transfer Protein Clarified by Atomistic and Coarse-grained Simulations

Cholesteryl ester transfer protein (CETP) transports cholesteryl esters, triglycerides, and phospholipids between different lipoprotein fractions in blood plasma. The inhibition of CETP has been shown to be a sound strategy to prevent and treat the development of coronary heart disease. We employed...

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Bibliographic Details
Main Authors: Koivuniemi, Artturi, Vuorela, Timo, Kovanen, Petri T., Vattulainen, Ilpo, Hyvönen, Marja T.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257282/
https://ncbi.nlm.nih.gov/pubmed/22253581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002299
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