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The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: A role in alternative polyadenylation and a potential link to 5′ capping and splicing
3′-end cleavage and subsequent polyadenylation are critical steps in mRNA maturation. The precise location where cleavage occurs [referred to as poly(A) site] is determined by a tripartite mechanism in which a A(A/U) UAAA hexamer, GU-rich downstream element and UGUA upstream element are recognized b...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Landes Bioscience
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256351/ https://ncbi.nlm.nih.gov/pubmed/21881408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.8.5.16040 |
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