Amyloid-Mediated Sequestration of Essential Proteins Contributes to Mutant Huntingtin Toxicity in Yeast

BACKGROUND: Polyglutamine expansion is responsible for several neurodegenerative disorders, among which Huntington disease is the most well-known. Studies in the yeast model demonstrated that both aggregation and toxicity of a huntingtin (htt) protein with an expanded polyglutamine region strictly d...

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Detaylı Bibliyografya
Asıl Yazarlar: Kochneva-Pervukhova, Natalia V., Alexandrov, Alexander I., Ter-Avanesyan, Michael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256205/
https://ncbi.nlm.nih.gov/pubmed/22253794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029832
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