Rescue of Dystrophic Skeletal Muscle by PGC-1α Involves a Fast to Slow Fiber Type Shift in the mdx Mouse

Increased utrophin expression is known to reduce pathology in dystrophin-deficient skeletal muscles. Transgenic over-expression of PGC-1α has been shown to increase levels of utrophin mRNA and improve the histology of mdx muscles. Other reports have shown that PGC-1α signaling can lead to increased...

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Detaylı Bibliyografya
Asıl Yazarlar: Selsby, Joshua T., Morine, Kevin J., Pendrak, Klara, Barton, Elisabeth R., Sweeney, H. Lee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256197/
https://ncbi.nlm.nih.gov/pubmed/22253880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030063
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