Stimulation of the Human RAD51 Nucleofilament Restricts HIV-1 Integration In Vitro and in Infected Cells

Stable HIV-1 replication requires the DNA repair of the integration locus catalyzed by cellular factors. The human RAD51 (hRAD51) protein plays a major role in homologous recombination (HR) DNA repair and was previously shown to interact with HIV-1 integrase (IN) and inhibit its activity. Here we de...

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Main Authors: Cosnefroy, O., Tocco, A., Lesbats, P., Thierry, S., Calmels, C., Wiktorowicz, T., Reigadas, S., Kwon, Y., De Cian, A., Desfarges, S., Bonot, P., San Filippo, J., Litvak, S., Le Cam, E., Rethwilm, A., Fleury, H., Connell, P. P., Sung, P., Delelis, O., Andréola, M. L., Parissi, V.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Cellular Response to Infection
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255893/
https://ncbi.nlm.nih.gov/pubmed/22013044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05425-11
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