DUAL AND OPPOSITE EFFECTS OF hRAD51 CHEMICAL MODULATION ON HIV-1 INTEGRATION

The cellular DNA repair hRAD51 protein has been shown to restrict HIV-1 integration both in vitro and in vivo. To investigate its regulatory functions, we performed a pharmacological analysis of the retroviral integration modulation by hRAD51. We found that, in vitro, chemical activation of hRAD51 s...

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Publicado en:Chem Biol
Autores principales: Thierry, Sylvain, Benleulmi, Mohamed Salah, Sinzelle, Ludivine, Thierry, Eloise, Calmels, Christina, Chaignepain, Stephane, Waffo-Teguo, Pierre, Merillon, Jean-Michel, Budke, Brian, Pasquet, Jean-Max, Litvak, Simon, Ciuffi, Angela, Sung, Patrick, Connell, Philip, Hauber, Ilona, Hauber, Joachim, Andreola, Marie-Line, Delelis, Olivier, Parissi, Vincent
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889029/
https://ncbi.nlm.nih.gov/pubmed/26051216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.04.020
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